The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T cells
Sesquiterpene lactones (SL) derived from Mexican India medicinal plants and parthenolide, the major SL from European feverfew, have raised considerable interest because of their anti-inflammatory and complex pharmacological action. Interleukin-4 (IL-4) is a key cytokine that influences the developme...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 November 2002
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| In: |
European journal of immunology
Year: 2002, Volume: 32, Issue: 12, Pages: 3587-3597 |
| ISSN: | 1521-4141 |
| DOI: | https://doi.org/10.1002/1521-4141(200212)32:12<3587::AID-IMMU3587>3.0.CO;2-E |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/1521-4141(200212)32:12<3587::AID-IMMU3587>3.0.CO;2-E Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-4141%28200212%2932%3A12%3C3587%3A%3AAID-IMMU3587%3E3.0.CO%3B2-E 
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| Author Notes: | Min Li‐Weber, Marco Giaisi, Monika K. Treiber and Peter H. Krammer |
| Summary: | Sesquiterpene lactones (SL) derived from Mexican India medicinal plants and parthenolide, the major SL from European feverfew, have raised considerable interest because of their anti-inflammatory and complex pharmacological action. Interleukin-4 (IL-4) is a key cytokine that influences the development of T helper 2 cells and plays an important role in the pathogenesis of allergic diseases. We show here that the anti-inflammatory parthenolide suppresses IL-4 expression at the mRNA and the protein levels in a dose-dependent manner. We demonstrate that parthenolide blocks NF-κB binding to two important IL-4 promoter regulatory elements and suppresses promoter activity upon T cell activation. Differences regarding the effects of parthenolide on expression levels of IL-4, IL-2 and IFN-γ were observed. Parthenolide (2.5 μM) could completely suppress IL-4 protein levels secreted in anti-CD3/CD28-stimulated peripheral blood T cells from allergic and normal donors.Complete inhibition of IL-2 and IFN-γ requires higher doses of parthenolide. So far, drugs directed against IL-4 expression have not been described. This finding raises the potential to develop parthenolide to treat IL-4-mediated allergic-like inflammation. |
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| Item Description: | Gesehen am 15.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1521-4141 |
| DOI: | https://doi.org/10.1002/1521-4141(200212)32:12<3587::AID-IMMU3587>3.0.CO;2-E |