Iron metabolism in high-altitude residents
Residents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data on how iron metabolism adapts when living in a hypoxic...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 Oct 2020
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| In: |
Journal of applied physiology
Year: 2020, Volume: 129, Issue: 4, Pages: 920-925 |
| ISSN: | 1522-1601 |
| DOI: | 10.1152/japplphysiol.00019.2020 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/japplphysiol.00019.2020 Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/japplphysiol.00019.2020 
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| Author Notes: | Martina U. Muckenthaler, Heimo Mairbäurl, and Max Gassmann |
| Summary: | Residents at high altitude cope with decreasing inspiratory oxygen partial pressure by stimulating erythropoiesis. The increase in hemoglobin levels requires high amounts of additional iron supplied from the diet. Here, we review available data on how iron metabolism adapts when living in a hypoxic environment. Our analysis reveals that long-term adaptation to high altitude enables healthy individuals to maintain their iron stores within the physiological range despite elevated requirements for erythropoiesis. However, in vulnerable populations with increased iron demand (e.g., pregnant women or exercising individuals), iron stores are less likely to be replenished quickly when living at high altitude. Future studies need to address whether different ethnicities have acquired genetic mechanisms to adapt to the elevated iron demand for erythropoiesis at high altitude. |
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| Item Description: | Gesehen am 15.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1522-1601 |
| DOI: | 10.1152/japplphysiol.00019.2020 |