Lovastatin induces mitotic abnormalities in various cell lines
We examined the effects of lovastatin, a common anti-atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G1phase, but also at the G2/M transition. After 24...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
02 January 2013
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| In: |
Cell biology international
Year: 1999, Jahrgang: 23, Heft: 1, Pages: 51-60 |
| ISSN: | 1095-8355 |
| DOI: | https://doi.org/10.1006/cbir.1998.0322 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1006/cbir.1998.0322 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1006/cbir.1998.0322 
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| Verfasserangaben: | Jan Lamprecht, Cezary Wójcik, Marek Jakóbisiak, Michael Stoehr, Dieter Schroeter and Neidhard Paweletz |
| Zusammenfassung: | We examined the effects of lovastatin, a common anti-atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G1phase, but also at the G2/M transition. After 24-48h incubation of epithelial PtK2, T24, HeLa cells and fibroblastic L929 cells in the presence of 1.0-60.0μm lovastatin, diverse mitotic perturbations have been observed. The most noteworthy phenomena recorded were prometaphase retardation and chromosome lagging during metaphase and anaphase. After the recovery in lovastatin-free media, the cells continued mitosis without any disturbances. Mevalonic acid prevented the effects of lovastatin. We conclude that the effects were specific for lovastatin-induced inhibition of mevalonic acid synthesis. Immunofluorescence studies with anticentromeric antibodies suggested that one of the possible causes of the lovastatin-induced mitotic disorder could be an interference with the development and function of the centromeres. |
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| Beschreibung: | Elektronische Reproduktion der Druckausgabe Gesehen am 16.04.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1095-8355 |
| DOI: | https://doi.org/10.1006/cbir.1998.0322 |