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Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly

Calcium/Calmodulin-dependent kinase alpha (alpha CaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the a...

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Main Authors: Rhein, Cosima (Author) , Mühle, Christiane (Author) , Lenz, Bernd (Author) , Richter-Schmidinger, Tanja (Author) , Kogias, Georgios (Author) , Boix, Fernando (Author) , Lourdusamy, Anbarasu (Author) , Dörfler, Arnd (Author) , Peters, Oliver (Author) , Ramirez, Alfredo (Author) , Jessen, Frank (Author) , Maier, Wolfgang (Author) , Hüll, Michael (Author) , Frölich, Lutz (Author) , Teipel, Stefan (Author) , Wiltfang, Jens (Author) , Kornhuber, Johannes (Author) , Müller, Christian P. (Author)
Format: Article (Journal)
Language:English
Published: 11 May 2020
In: Brain research bulletin
Year: 2020, Volume: 161, Pages: 13-20
ISSN:1873-2747
DOI:10.1016/j.brainresbull.2020.05.001
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.brainresbull.2020.05.001
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Author Notes:Cosima Rhein, Christiane Mühle, Bernd Lenz, Tanja Richter-Schmidinger, Georgios Kogias, Fernando Boix, Anbarasu Lourdusamy, Arnd Dörfler, Oliver Peters, Alfredo Ramirez, Frank Jessen, Wolfgang Maier, Michael Hüll, Lutz Frölich, Stefan Teipel, Jens Wiltfang, Johannes Kornhuber, Christian P. Müller
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Summary:Calcium/Calmodulin-dependent kinase alpha (alpha CaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the alpha CaMKII coding gene CAMK2A in verbal logical memory in two Caucasian populations from Germany, in a sample of 209 elderly people with cognitive impairments and a sample of 142 healthy adults. The association of single nucleotide polymorphisms (SNPs) located within the genomic region of CAMK2A with verbal logical memory learning and retrieval from the Wechsler Memory Scale was measured and hippocampal volume was assessed by structural MRI. In the elderly people, we found the minor allele of CAMK2A intronic SNP rs919741 to predict a higher hippocampal volume and better logical memory retrieval. This association was not found in healthy adults. The present study may provide evidence for an association of a genetic variant of the CAMK2A gene specifically with retrieval of logical memory in elderly humans. This effect is possibly mediated by a higher hippocampal volume.
Item Description:Gesehen am 16.04.2021
Physical Description:Online Resource
ISSN:1873-2747
DOI:10.1016/j.brainresbull.2020.05.001

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