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Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency

While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells, prospective LSC enrichment has been hampered by the intranuclear localization of the prev...

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Hauptverfasser: Norrick, Alexandra (VerfasserIn) , Esterlechner, Jasmina (VerfasserIn) , Niebergall-Roth, Elke (VerfasserIn) , Dehio, Ulf (VerfasserIn) , Sadeghi, Samar (VerfasserIn) , Schröder, Hannes M. (VerfasserIn) , Ballikaya, Seda (VerfasserIn, BerichterstatterIn) , Stemler, Nicole (VerfasserIn) , Ganss, Christoph (VerfasserIn) , Dieter, Kathrin (VerfasserIn) , Dachtler, Ann-Kathrin (VerfasserIn) , Merz, Patrick (VerfasserIn) , Sel, Saadettin (VerfasserIn) , Chodosh, James (VerfasserIn) , Cursiefen, Claus (VerfasserIn) , Frank, Natasha Y. (VerfasserIn) , Auffarth, Gerd U. (VerfasserIn) , Ksander, Bruce (VerfasserIn) , Frank, Markus H. (VerfasserIn) , Kluth, Mark A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 19 March 2021
In: Stem cell research & therapy
Year: 2021, Jahrgang: 12, Pages: 1-21
ISSN:1757-6512
DOI:10.1186/s13287-021-02272-2
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13287-021-02272-2
Volltext
Verfasserangaben:Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank, Gerd U. Auffarth, Bruce Ksander, Markus H. Frank and Mark A. Kluth
Beschreibung
Zusammenfassung:While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells, prospective LSC enrichment has been hampered by the intranuclear localization of the previously reported LSC marker p63. The recent identification of the ATP-binding cassette transporter ABCB5 as a plasma membrane-spanning marker of LSCs that are capable of restoring the cornea and the development of an antibody directed against an extracellular loop of the ABCB5 molecule stimulated us to develop a novel treatment strategy based on the utilization of in vitro expanded allogeneic ABCB5+ LSCs derived from human cadaveric limbal tissue.
Beschreibung:Im Titel ist "+" hochgestellt
Gesehen am 16.04.2021
Beschreibung:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-021-02272-2

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