Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency

While therapeutic success of the limbal tissue or cell transplantation to treat severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the percentage of LSCs within the transplanted cells, prospective LSC enrichment has been hampered by the intranuclear localization of the prev...

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Main Authors:	Norrick, Alexandra (Author) , Esterlechner, Jasmina (Author) , Niebergall-Roth, Elke (Author) , Dehio, Ulf (Author) , Sadeghi, Samar (Author) , Schröder, Hannes M. (Author) , Ballikaya, Seda (Author, Other) , Stemler, Nicole (Author) , Ganss, Christoph (Author) , Dieter, Kathrin (Author) , Dachtler, Ann-Kathrin (Author) , Merz, Patrick (Author) , Sel, Saadettin (Author) , Chodosh, James (Author) , Cursiefen, Claus (Author) , Frank, Natasha Y. (Author) , Auffarth, Gerd U. (Author) , Ksander, Bruce (Author) , Frank, Markus H. (Author) , Kluth, Mark A. (Author)
Format:	Article (Journal)
Language:	English
Published:	19 March 2021
In:	Stem cell research & therapy Year: 2021, Volume: 12, Pages: 1-21
ISSN:	1757-6512
DOI:	10.1186/s13287-021-02272-2
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13287-021-02272-2
Author Notes:	Alexandra Norrick, Jasmina Esterlechner, Elke Niebergall-Roth, Ulf Dehio, Samar Sadeghi, Hannes M. Schröder, Seda Ballikaya, Nicole Stemler, Christoph Ganss, Kathrin Dieter, Ann-Kathrin Dachtler, Patrick Merz, Saadettin Sel, James Chodosh, Claus Cursiefen, Natasha Y. Frank, Gerd U. Auffarth, Bruce Ksander, Markus H. Frank and Mark A. Kluth