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Stability of 11-nor-Δ9-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry

Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present in considerably higher concentrations than the parent drug. Acyl glucuronides have been shown to be potentially reactive conjugates, whi...

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Bibliographic Details
Main Authors: Skopp, Gisela (Author) , Pötsch-Schneider, Lucia Edeltraud (Author)
Format: Article (Journal)
Language:English
Published: 01 February 2002
In: Clinical chemistry
Year: 2002, Volume: 48, Issue: 2, Pages: 301-306
ISSN:1530-8561
DOI:10.1093/clinchem/48.2.301
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/clinchem/48.2.301
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/clinchem/article/48/2/301/5641524
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Author Notes:Gisela Skopp and Lucia Pötsch
Description
Summary:Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present in considerably higher concentrations than the parent drug. Acyl glucuronides have been shown to be potentially reactive conjugates, which may affect the in vitro metabolite pattern.
Item Description:Im Titel erscheint die Ziffer 9 hochgestellt
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Physical Description:Online Resource
ISSN:1530-8561
DOI:10.1093/clinchem/48.2.301

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