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Stability of 11-nor-Δ9-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry

Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present in considerably higher concentrations than the parent drug. Acyl glucuronides have been shown to be potentially reactive conjugates, whi...

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Hauptverfasser: Skopp, Gisela (VerfasserIn) , Pötsch-Schneider, Lucia Edeltraud (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 February 2002
In: Clinical chemistry
Year: 2002, Jahrgang: 48, Heft: 2, Pages: 301-306
ISSN:1530-8561
DOI:10.1093/clinchem/48.2.301
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/clinchem/48.2.301
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/clinchem/article/48/2/301/5641524
Volltext
Verfasserangaben:Gisela Skopp and Lucia Pötsch
Beschreibung
Zusammenfassung:Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present in considerably higher concentrations than the parent drug. Acyl glucuronides have been shown to be potentially reactive conjugates, which may affect the in vitro metabolite pattern.
Beschreibung:Im Titel erscheint die Ziffer 9 hochgestellt
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Beschreibung:Online Resource
ISSN:1530-8561
DOI:10.1093/clinchem/48.2.301

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