Intensity modulated radiation therapy (IMRT) with simultaneously integrated boost shortens treatment time and Is noninferior to conventional radiation therapy followed by sequential boost in adjuvant breast cancer treatment: results of a large randomized phase III trial (IMRT-MC2 trial)

In the modern era, improvements in radiation therapy techniques have paved the way for simultaneous integrated boost irradiation in adjuvant breast radiation therapy after breast conservation surgery. Nevertheless, randomized trials supporting the noninferiority of this treatment to historical stand...

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Main Authors: Hörner-Rieber, Juliane (Author) , Forster, Tobias (Author) , Hommertgen, Adriane (Author) , Häfner, Matthias (Author) , Arians, Nathalie (Author) , König, Laila (Author) , Harrabi, Semi B. (Author) , Schlampp, Ingmar (Author) , Weykamp, Fabian (Author) , Lischalk, Jonathan W (Author) , Heinrich, Vanessa (Author) , Weidner, Nicola (Author) , Hüsing, Johannes (Author) , Sohn, Christof (Author) , Heil, Jörg (Author) , Hof, Holger (Author) , Krug, David (Author) , Debus, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: International journal of radiation oncology, biology, physics
Year: 2020, Volume: 109, Issue: 5, Pages: 1311-1324
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2020.12.005
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2020.12.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0360301620346514
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Author Notes:Juliane Hörner-Rieber, Tobias Forster, Adriane Hommertgen, Matthias F. Haefner, Nathalie Arians, Laila König, Semi B. Harrabi, Ingmar Schlampp, Fabian Weykamp, Jonathan W. Lischalk, Vanessa Heinrich, Nicola Weidner, Johannes Hüsing, Christof Sohn, Jörrg Heil, Holger Hof, David Krug, and Jürgen Debus
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Summary:In the modern era, improvements in radiation therapy techniques have paved the way for simultaneous integrated boost irradiation in adjuvant breast radiation therapy after breast conservation surgery. Nevertheless, randomized trials supporting the noninferiority of this treatment to historical standards of care approach are lacking.
Item Description:Available online 13 December 2020
Gesehen am 23.04.2021
Physical Description:Online Resource
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2020.12.005