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Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells

Efficient activation of antigen-specific T cells requires co-stimulatory signals provided e.g. by CD28. Re-exposure to antigen and CD28 co-stimulation reduces activation-induced cell death (AICD) and increases the number of T cells performing effector functions. AICD is mediated predominantly by CD9...

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Bibliographic Details
Main Authors: Kirchhoff, Sabine (Author) , Li-Weber, Min (Author) , Krammer, Peter H. (Author)
Format: Article (Journal)
Language:English
Published: 29 November 2000
In: European journal of immunology
Year: 2000, Volume: 30, Issue: 10, Pages: 2765-2774
ISSN:1521-4141
DOI:https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-4141%28200010%2930%3A10%3C2765%3A%3AAID-IMMU2765%3E3.0.CO%3B2-W
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Author Notes:Sabine Kirchhoff, Wolfgang W. Müller, Min Li‐Weber and Peter H. Krammer
Description
Summary:Efficient activation of antigen-specific T cells requires co-stimulatory signals provided e.g. by CD28. Re-exposure to antigen and CD28 co-stimulation reduces activation-induced cell death (AICD) and increases the number of T cells performing effector functions. AICD is mediated predominantly by CD95 (APO-1/Fas) and its cognate ligand (CD95L). In an in vitro model system, using human peripheral activated T cells, we demonstrate here that co-stimulation prevents CD95L expression. Moreover, we show that co-stimulation reduces the activity of the CD95 death-inducing signaling complex and procaspase-8 activation. In parallel, co-stimulation strongly increases expression of the short form of the FLICE-inhibitory protein c-FLIPshort and of Bcl-xL. These data provide important new insight into the molecular mechanisms of apoptosis resistance in co-stimulated T cells.
Item Description:Gesehen am 26.04.2021
Im Titel ist der Ausdruck "short" tiefgestellt
Physical Description:Online Resource
ISSN:1521-4141
DOI:https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W

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