Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells
Efficient activation of antigen-specific T cells requires co-stimulatory signals provided e.g. by CD28. Re-exposure to antigen and CD28 co-stimulation reduces activation-induced cell death (AICD) and increases the number of T cells performing effector functions. AICD is mediated predominantly by CD9...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 November 2000
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| In: |
European journal of immunology
Year: 2000, Volume: 30, Issue: 10, Pages: 2765-2774 |
| ISSN: | 1521-4141 |
| DOI: | https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/1521-4141%28200010%2930%3A10%3C2765%3A%3AAID-IMMU2765%3E3.0.CO%3B2-W 
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| Author Notes: | Sabine Kirchhoff, Wolfgang W. Müller, Min Li‐Weber and Peter H. Krammer |
MARC
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| 520 | |a Efficient activation of antigen-specific T cells requires co-stimulatory signals provided e.g. by CD28. Re-exposure to antigen and CD28 co-stimulation reduces activation-induced cell death (AICD) and increases the number of T cells performing effector functions. AICD is mediated predominantly by CD95 (APO-1/Fas) and its cognate ligand (CD95L). In an in vitro model system, using human peripheral activated T cells, we demonstrate here that co-stimulation prevents CD95L expression. Moreover, we show that co-stimulation reduces the activity of the CD95 death-inducing signaling complex and procaspase-8 activation. In parallel, co-stimulation strongly increases expression of the short form of the FLICE-inhibitory protein c-FLIPshort and of Bcl-xL. These data provide important new insight into the molecular mechanisms of apoptosis resistance in co-stimulated T cells. | ||
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