Suppression by GABAB receptors of 4-aminopyridine-induced hyperactivity in guinea-pig dentate neurons
Double intracellular recording from granule cells and hilar neurons was performed in hippocampal slices to study the effect of γ-aminobutyric acid (GABA) receptor antagonists on the activity induced by the convulsant 4-aminopyridine (4-AP) in the dentate gyrus. 4-AP evoked GABA-mediated responses in...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1996
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| In: |
Neuroscience letters
Year: 1996, Volume: 205, Issue: 1, Pages: 49-52 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/0304-3940(96)12368-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0304-3940(96)12368-5 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/0304394096123685 
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| Author Notes: | Maria Bijak, Ulrich Misgeld |
| Summary: | Double intracellular recording from granule cells and hilar neurons was performed in hippocampal slices to study the effect of γ-aminobutyric acid (GABA) receptor antagonists on the activity induced by the convulsant 4-aminopyridine (4-AP) in the dentate gyrus. 4-AP evoked GABA-mediated responses in granule cells and burst discharges in hilar neurons. In the presence of GABAB but not GABAA receptor antagonists, 4-AP evoked discharge activity in dentate granule cells. When both GABAA and GABAB receptors were blocked 4-AP induced synchronous ‘paroxysmal depolarizing shift’-like activity in granule cells and hilar neurons. Our data indicate that GABAB receptor-mediated mechanisms protect dentate cells against the convulsant effects of 4-AP |
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| Item Description: | Im Text ist das letzte "B" bei GABAB tiefgestellt Elektronische Reproduktion der Druck-Ausgabe Online 2 March 1999 Gesehen am 27.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/0304-3940(96)12368-5 |