γ-Aminobutyric acidB autoreceptors in substantia nigra and neostriatum of the weaver mutant mouse
The weaver mutation causes cell loss in the center of the substantia nigra, pars compacta. We compared the depression of γ-aminobutyric acid (GABA)A synaptic currents by the GABAB agonist R-baclofen in pars compacta neurons of weaver mice which were largely spared from cell degeneration and of wild-...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 February 2001
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| In: |
Neuroscience letters
Year: 2001, Volume: 299, Issue: 1, Pages: 81-84 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/S0304-3940(01)01496-3 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3940(01)01496-3 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304394001014963 
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| Author Notes: | Gabriele Radnikow, Stefan Titz, Sandra Mades, Jörg Bäurle, Ulrich Misgeld |
| Summary: | The weaver mutation causes cell loss in the center of the substantia nigra, pars compacta. We compared the depression of γ-aminobutyric acid (GABA)A synaptic currents by the GABAB agonist R-baclofen in pars compacta neurons of weaver mice which were largely spared from cell degeneration and of wild-type mice. In weaver neurons the suppression of GABAA synaptic currents by R-baclofen was reduced compared to wild-type neurons. The EC50 of R-baclofen was 6.3 times higher in weaver than in wild-type mice. In the neostriatum, which is not a target of the mutation, such a difference did not exist. We conclude that in the pars compacta the weaver mutation leads to a reduced presynaptic autoinhibition through GABAB receptors which may promote survival of a subset of weaver neurons in the pars compacta. |
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| Item Description: | Im Text ist "B" bei acidB tiefgestellt Gesehen am 27.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/S0304-3940(01)01496-3 |