Map of spinal neurons activated by chemical stimulation in the nucleus raphe magnus of the unanesthetized rat
The expression of the proto-oncogene c-fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased imm...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1995
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| In: |
Neuroscience
Year: 1995, Volume: 67, Issue: 2, Pages: 497-504 |
| ISSN: | 1873-7544 |
| DOI: | 10.1016/0306-4522(95)00017-D |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0306-4522(95)00017-D Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/030645229500017D 
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| Author Notes: | K. Bett, and J. Sandkühler |
| Summary: | The expression of the proto-oncogene c-fos was used as a cellular marker of spinal cord neurons activated by microinjection of kainic acid into the medullary nucleus raphe magnus of awake and drug-free Sprague-Dawley rats. The c-FOS protein was detected by immunocytochemistry. We found increased immunoreactivity bilaterally in laminae I-VI of the dorsal horn. The strongest c-FOS expression was observed within the inner layer of lamina II near its border with lamina III. In the ventral horn no c-FOS immunoreactivity was observed. Thus, the present results provide evidence for a descending excitation of neurons predominantly in inner lamina II, possibly mediating nucleus raphe magnus-induced inhibition of neurons in other laminae. |
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| Item Description: | Online 6 April 2000 Elektronische Reproduktion der Druck-Ausgabe Gesehen am 28.04.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1873-7544 |
| DOI: | 10.1016/0306-4522(95)00017-D |