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Validation and reference values of the EORTC QLQ-CML24 questionnaire to assess health-related quality of life in patients with chronic myeloid leukemia

Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors...

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Main Authors: Efficace, Fabio (Author) , Iurlo, Alessandra (Author) , Patriarca, Andrea (Author) , Stagno, Fabio (Author) , Bee, Ping-Chong (Author) , Ector, Geneviève (Author) , Capodanno, Isabella (Author) , Elena, Chiara (Author) , Bonifacio, Massimiliano (Author) , Blijlevens, Nicole M. A. (Author) , Caocci, Giovanni (Author) , Wan, Chonghua (Author) , Abruzzese, Elisabetta (Author) , Breccia, Massimo (Author) , Cottone, Francesco (Author) , Okumura, Iris (Author) , Oerlemans, Simone (Author) , Cascavilla, Nicola (Author) , Albano, Francesco (Author) , Kota, Vamsi (Author) , Sztankay, Monika (Author) , Miggiano, Maria Cristina (Author) , Saußele, Susanne (Author) , Renzo, Nicola Di (Author) , Sorà, Federica (Author) , Castagnetti, Fausto (Author) , Baccarani, Michele (Author) , Vignetti, Marco (Author) , Rosti, Gianantonio (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Leukemia and lymphoma
Year: 2020, Volume: 62, Issue: 3, Pages: 669-678
ISSN:1029-2403
DOI:10.1080/10428194.2020.1838509
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/10428194.2020.1838509
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Author Notes:Fabio Efficace, Alessandra Iurlo, Andrea Patriarca, Fabio Stagno, Ping-Chong Bee, Geneviève Ector, Isabella Capodanno, Chiara Elena, Massimiliano Bonifacio, Nicole M. A. Blijlevens, Giovanni Caocci, Chonghua Wan, Elisabetta Abruzzese, Massimo Breccia, Francesco Cottone, Iris Okumura, Simone Oerlemans, Nicola Cascavilla, Francesco Albano, Vamsi Kota, Monika Sztankay, Maria Cristina Miggiano, Susanne Saussele, Nicola Di Renzo, Federica Sorà, Fausto Castagnetti, Michele Baccarani, Marco Vignetti, Gianantonio Rosti
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Summary:Health-related quality of life (HRQOL) assessment is important to facilitate decisions in the current treatment landscape of chronic myeloid leukemia (CML). Therefore, the availability of a validated HRQOL questionnaire, specifically developed for CML patients treated with tyrosine kinase inhibitors (TKIs), may enhance quality of research in this area. We performed an international study including 782 CML patients to assess the validity of the EORTC QLQ-CML 24 questionnaire, and to generate HRQOL reference values to facilitate interpretation of results in future studies. Internal consistency, assessed with Cronbach’s alpha coefficients, ranged from 0.66 to 0.83. In the confirmatory factor analysis, all standardized factor loadings exceeded the threshold of 0.40 (range 0.49-0.97), confirming the hypothesized scale structure. Reference values stratified by age and sex were also generated. Our findings support the use of the EORTC QLQ-CML 24, in conjunction with the EORTC QLQ-C30, as a valuable measure to assess HRQOL in CML patients.
Item Description:Gesehen am 28.04.2021
Published online: 06 Nov 2020
Physical Description:Online Resource
ISSN:1029-2403
DOI:10.1080/10428194.2020.1838509

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