Maturation block in childhood cancer
Summary: The key differences between tumors arising in children and those in adults stem from the cellular origin of cancer at different ages, with adult cancers arising within aging cell hierarchies, as a consequence of accumulated damage and mutagenesis, in contrast to childhood tumors that are bo...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 15, 2021
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| In: |
Cancer discovery
Year: 2021, Volume: 11, Issue: 3, Pages: 542-544 |
| ISSN: | 2159-8290 |
| DOI: | 10.1158/2159-8290.CD-20-0926 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/2159-8290.CD-20-0926 Verlag, lizenzpflichtig, Volltext: https://cancerdiscovery.aacrjournals.org/content/11/3/542 
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| Author Notes: | Sam Behjati, Richard J. Gilbertson, and Stefan M. Pfister |
| Summary: | Summary: The key differences between tumors arising in children and those in adults stem from the cellular origin of cancer at different ages, with adult cancers arising within aging cell hierarchies, as a consequence of accumulated damage and mutagenesis, in contrast to childhood tumors that are born in aberrantly developing tissues. A distinct biological property of childhood tumor cells—a block of developmental maturation—may hold the key to advancing the treatment of childhood cancer beyond cytotoxic strategies. |
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| Item Description: | Gesehen am 03.08.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2159-8290 |
| DOI: | 10.1158/2159-8290.CD-20-0926 |