Cover Image

Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany

Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder. - Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG-associate...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Jia (Author) , Mori, Masahiro (Author) , Zimmermann, Hanna (Author) , Brandt, Alexander (Author) , Havla, Joachim (Author) , Tanaka, Satoru (Author) , Sugimoto, Kazuo (Author) , Oji, Satoru (Author) , Uzawa, Akiyuki (Author) , Asseyer, Susanna (Author) , Cooper, Graham (Author) , Jarius, Sven (Author) , Bellmann-Strobl, Judith (Author) , Ruprecht, Klemens (Author) , Siebert, Nadja (Author) , Masuda, Hiroki (Author) , Uchida, Tomohiko (Author) , Ohtani, Ryohei (Author) , Nomura, Kyoichi (Author) , Meinl, Edgar (Author) , Kuempfel, Tania (Author) , Paul, Friedemann (Author) , Kuwabara, Satoshi (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Journal of neurology, neurosurgery, and psychiatry
Year: 2021, Volume: 92, Issue: 4, Pages: 377-383
ISSN:1468-330X
DOI:10.1136/jnnp-2020-324422
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jnnp-2020-324422
Verlag, lizenzpflichtig, Volltext: https://jnnp.bmj.com/content/92/4/377
Get full text
Author Notes:Jia Liu, Masahiro Mori, Hanna Zimmermann, Alexander Brandt, Joachim Havla, Satoru Tanaka, Kazuo Sugimoto, Satoru Oji, Akiyuki Uzawa, Susanna Asseyer, Graham Cooper, Sven Jarius, Judith Bellmann-Strobl, Klemens Ruprecht, Nadja Siebert, Hiroki Masuda, Tomohiko Uchida, Ryohei Ohtani, Kyoichi Nomura, Edgar Meinl, Tania Kuempfel, Friedemann Paul, Satoshi Kuwabara
Description
Summary:Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder. - Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG-associated disorders between East Asian (Japanese) and Caucasian (German) patients. - Methods Demographic, clinical and therapeutic data from 68 MOG-IgG-positive adults were collected (Japanese, n=44; German, n=24). - Results Age and sex were similar between cohorts, with optic neuritis occurring most frequently at onset (Japanese: 61%; German: 58%). However, Japanese patients had a lower annualised relapse rate (0.4 vs 0.8, p=0.019; no relapse, 64% vs 25%, p=0.002) and lower Expanded Disability Status Scale score at the last visit (1.0 vs 2.0; p=0.008), despite similar follow-up periods (mean, 73.9 months vs 73.4 months), than those of German patients, respectively. Cerebral syndromes were more common (27% vs 4%; p=0.021) and myelitis less common (21% vs 50%; p=0.012) in Japanese than in German patients, respectively. Japanese patients were more commonly treated with long-term corticosteroids (73%), whereas German patients were more commonly treated with rituximab or other immunosuppressants (63%). - Conclusions Among patients with MOG-IgG, Japanese tended to have a monophasic milder disease, whereas the majority of German patients had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica spectrum disorder. Although the attack-prevention treatment regimens were considerably different, genetic and environmental factors may be important to determine clinical phenotypes and disease activity.
Item Description:Published online first 20 November 2020
Gesehen am 30.07.2021
Physical Description:Online Resource
ISSN:1468-330X
DOI:10.1136/jnnp-2020-324422

Similar Items