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Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany

Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder. - Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG-associate...

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Hauptverfasser: Liu, Jia (VerfasserIn) , Mori, Masahiro (VerfasserIn) , Zimmermann, Hanna (VerfasserIn) , Brandt, Alexander (VerfasserIn) , Havla, Joachim (VerfasserIn) , Tanaka, Satoru (VerfasserIn) , Sugimoto, Kazuo (VerfasserIn) , Oji, Satoru (VerfasserIn) , Uzawa, Akiyuki (VerfasserIn) , Asseyer, Susanna (VerfasserIn) , Cooper, Graham (VerfasserIn) , Jarius, Sven (VerfasserIn) , Bellmann-Strobl, Judith (VerfasserIn) , Ruprecht, Klemens (VerfasserIn) , Siebert, Nadja (VerfasserIn) , Masuda, Hiroki (VerfasserIn) , Uchida, Tomohiko (VerfasserIn) , Ohtani, Ryohei (VerfasserIn) , Nomura, Kyoichi (VerfasserIn) , Meinl, Edgar (VerfasserIn) , Kuempfel, Tania (VerfasserIn) , Paul, Friedemann (VerfasserIn) , Kuwabara, Satoshi (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2021
In: Journal of neurology, neurosurgery, and psychiatry
Year: 2021, Jahrgang: 92, Heft: 4, Pages: 377-383
ISSN:1468-330X
DOI:10.1136/jnnp-2020-324422
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jnnp-2020-324422
Verlag, lizenzpflichtig, Volltext: https://jnnp.bmj.com/content/92/4/377
Volltext
Verfasserangaben:Jia Liu, Masahiro Mori, Hanna Zimmermann, Alexander Brandt, Joachim Havla, Satoru Tanaka, Kazuo Sugimoto, Satoru Oji, Akiyuki Uzawa, Susanna Asseyer, Graham Cooper, Sven Jarius, Judith Bellmann-Strobl, Klemens Ruprecht, Nadja Siebert, Hiroki Masuda, Tomohiko Uchida, Ryohei Ohtani, Kyoichi Nomura, Edgar Meinl, Tania Kuempfel, Friedemann Paul, Satoshi Kuwabara
Beschreibung
Zusammenfassung:Background Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder. - Objective The study aimed to identify regional and ethnic differences in clinical profiles of MOG-IgG-associated disorders between East Asian (Japanese) and Caucasian (German) patients. - Methods Demographic, clinical and therapeutic data from 68 MOG-IgG-positive adults were collected (Japanese, n=44; German, n=24). - Results Age and sex were similar between cohorts, with optic neuritis occurring most frequently at onset (Japanese: 61%; German: 58%). However, Japanese patients had a lower annualised relapse rate (0.4 vs 0.8, p=0.019; no relapse, 64% vs 25%, p=0.002) and lower Expanded Disability Status Scale score at the last visit (1.0 vs 2.0; p=0.008), despite similar follow-up periods (mean, 73.9 months vs 73.4 months), than those of German patients, respectively. Cerebral syndromes were more common (27% vs 4%; p=0.021) and myelitis less common (21% vs 50%; p=0.012) in Japanese than in German patients, respectively. Japanese patients were more commonly treated with long-term corticosteroids (73%), whereas German patients were more commonly treated with rituximab or other immunosuppressants (63%). - Conclusions Among patients with MOG-IgG, Japanese tended to have a monophasic milder disease, whereas the majority of German patients had a relapsing course and more frequent myelitis, findings compatible with neuromyelitis optica spectrum disorder. Although the attack-prevention treatment regimens were considerably different, genetic and environmental factors may be important to determine clinical phenotypes and disease activity.
Beschreibung:Published online first 20 November 2020
Gesehen am 30.07.2021
Beschreibung:Online Resource
ISSN:1468-330X
DOI:10.1136/jnnp-2020-324422

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