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Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb

Neurogenesis underlies plastic changes in defined neuronal circuits in the postnatal and adult brain. Here we identify connective tissue growth factor (CTGF) as a critical factor in the mouse olfactory bulb (OB) in determining the efficiency of incorporation of postnatally born inhibitory neurons, t...

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Main Authors: Khodosevich, Konstantin (Author) , Lazarini, Françoise (Author) , Engelhardt, Jakob von (Author) , Kaneko, Hiroshi (Author) , Lledo, Pierre-Marie (Author) , Monyer, Hannah (Author)
Format: Article (Journal)
Language:English
Published: 29 August 2013
In: Neuron
Year: 2013, Volume: 79, Issue: 6, Pages: 1136-1151
ISSN:1097-4199
DOI:10.1016/j.neuron.2013.07.011
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuron.2013.07.011
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0896627313006119
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Author Notes:Konstantin Khodosevich, Françoise Lazarini, Jakob von Engelhardt, Hiroshi Kaneko, Pierre-Marie Lledo, and Hannah Monyer
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Summary:Neurogenesis underlies plastic changes in defined neuronal circuits in the postnatal and adult brain. Here we identify connective tissue growth factor (CTGF) as a critical factor in the mouse olfactory bulb (OB) in determining the efficiency of incorporation of postnatally born inhibitory neurons, thus gating the output of glomeruli, the first relay station of olfactory processing in the brain. In the OB, CTGF expression was restricted to prenatally born external tufted cells. CTGF enhanced the proapoptotic activity of glial-derived TGF-β2, decreasing the survival of periglomerular inhibitory neurons. Changes in CTGF expression levels in the OB led to modifications in local neuronal circuitry and olfactory behaviors. We show that the odorant-specific recruitment of distinct glomeruli resulted in enhanced local CTGF expression levels in the activated glomeruli. Collectively our data reveal a molecular mechanism controlling the survival of defined postnatally born neurons, thus adapting neuronal integration to the sensory experiences.
Item Description:Gesehen am 29.04.2021
Physical Description:Online Resource
ISSN:1097-4199
DOI:10.1016/j.neuron.2013.07.011

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