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Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients

Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONM...

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Hauptverfasser: Quintairos, Luis (VerfasserIn) , Colom, Helena (VerfasserIn) , Millán, Olga (VerfasserIn) , Fortuna, Virginia (VerfasserIn) , Espinosa, Cristina (VerfasserIn) , Guirado, Lluis (VerfasserIn) , Budde, Klemens (VerfasserIn) , Sommerer, Claudia (VerfasserIn) , Lizana, Ana (VerfasserIn) , López-Púa, Yolanda (VerfasserIn) , Brunet, Mercè (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 22, 2021
In: PLOS ONE
Year: 2021, Jahrgang: 16, Heft: 1, Pages: 1-20
ISSN:1932-6203
DOI:10.1371/journal.pone.0245880
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0245880
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245880
Volltext
Verfasserangaben:Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet
Beschreibung
Zusammenfassung:Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR.
Beschreibung:Gesehen am 04.05.2021
Beschreibung:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0245880

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