Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONM...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 22, 2021
|
| In: |
PLOS ONE
Year: 2021, Volume: 16, Issue: 1, Pages: 1-20 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0245880 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0245880 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245880 
|
| Author Notes: | Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1757048634 | ||
| 003 | DE-627 | ||
| 005 | 20230426114231.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210504s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0245880 |2 doi | |
| 035 | |a (DE-627)1757048634 | ||
| 035 | |a (DE-599)KXP1757048634 | ||
| 035 | |a (OCoLC)1341407852 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Quintairos, Luis |e VerfasserIn |0 (DE-588)1232739707 |0 (DE-627)1757049355 |4 aut | |
| 245 | 1 | 0 | |a Early prognostic performance of miR155-5p monitoring for the risk of rejection |b Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients |c Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet |
| 264 | 1 | |c January 22, 2021 | |
| 300 | |a 20 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.05.2021 | ||
| 520 | |a Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR. | ||
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Glomerular filtration rate | |
| 650 | 4 | |a Kidneys | |
| 650 | 4 | |a Medical risk factors | |
| 650 | 4 | |a Normal distribution | |
| 650 | 4 | |a Pharmacokinetics | |
| 650 | 4 | |a Renal transplantation | |
| 650 | 4 | |a Simulation and modeling | |
| 700 | 1 | |a Colom, Helena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Millán, Olga |e VerfasserIn |0 (DE-588)1155423313 |0 (DE-627)1017711968 |0 (DE-576)501633200 |4 aut | |
| 700 | 1 | |a Fortuna, Virginia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Espinosa, Cristina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guirado, Lluis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Budde, Klemens |e VerfasserIn |0 (DE-588)1111064571 |0 (DE-627)865478902 |0 (DE-576)475913329 |4 aut | |
| 700 | 1 | |a Sommerer, Claudia |d 1971- |e VerfasserIn |0 (DE-588)121857654 |0 (DE-627)705680002 |0 (DE-576)292921829 |4 aut | |
| 700 | 1 | |a Lizana, Ana |e VerfasserIn |4 aut | |
| 700 | 1 | |a López-Púa, Yolanda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brunet, Mercè |e VerfasserIn |0 (DE-588)1188444077 |0 (DE-627)1667401173 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 16(2021), 1, Artikel-ID e0245880, Seite 1-20 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Early prognostic performance of miR155-5p monitoring for the risk of rejection Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients |
| 773 | 1 | 8 | |g volume:16 |g year:2021 |g number:1 |g elocationid:e0245880 |g pages:1-20 |g extent:20 |a Early prognostic performance of miR155-5p monitoring for the risk of rejection Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0245880 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245880 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210504 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 121857654 |a Sommerer, Claudia |m 121857654:Sommerer, Claudia |d 50000 |e 50000PS121857654 |k 0/50000/ |p 8 | ||
| 999 | |a KXP-PPN1757048634 |e 3922717357 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"523574592","pubHistory":["1.2006 -"],"corporate":[{"display":"Public Library of Science","role":"isb"}],"name":{"displayForm":["Public Library of Science"]},"origin":[{"publisherPlace":"San Francisco, California, US ; Lawrence, Kan.","publisher":"PLOS ; PLoS","dateIssuedDisp":"2006-","dateIssuedKey":"2006"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Early prognostic performance of miR155-5p monitoring for the risk of rejection Logistic regression with a population pharmacokinetic approach in adult kidney transplant patientsPLOS ONE","id":{"zdb":["2267670-3"],"eki":["523574592"],"issn":["1932-6203"]},"language":["eng"],"title":[{"title_sort":"PLOS ONE","title":"PLOS ONE"}],"part":{"text":"16(2021), 1, Artikel-ID e0245880, Seite 1-20","issue":"1","volume":"16","pages":"1-20","extent":"20","year":"2021"}}],"title":[{"title_sort":"Early prognostic performance of miR155-5p monitoring for the risk of rejection","title":"Early prognostic performance of miR155-5p monitoring for the risk of rejection","subtitle":"Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients"}],"language":["eng"],"id":{"doi":["10.1371/journal.pone.0245880"],"eki":["1757048634"]},"recId":"1757048634","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 04.05.2021"],"person":[{"display":"Quintairos, Luis","family":"Quintairos","role":"aut","given":"Luis"},{"display":"Colom, Helena","family":"Colom","role":"aut","given":"Helena"},{"display":"Millán, Olga","family":"Millán","role":"aut","given":"Olga"},{"family":"Fortuna","display":"Fortuna, Virginia","given":"Virginia","role":"aut"},{"role":"aut","given":"Cristina","display":"Espinosa, Cristina","family":"Espinosa"},{"display":"Guirado, Lluis","family":"Guirado","role":"aut","given":"Lluis"},{"role":"aut","given":"Klemens","display":"Budde, Klemens","family":"Budde"},{"given":"Claudia","role":"aut","family":"Sommerer","display":"Sommerer, Claudia"},{"given":"Ana","role":"aut","family":"Lizana","display":"Lizana, Ana"},{"role":"aut","given":"Yolanda","display":"López-Púa, Yolanda","family":"López-Púa"},{"role":"aut","given":"Mercè","display":"Brunet, Mercè","family":"Brunet"}],"physDesc":[{"extent":"20 S."}],"origin":[{"dateIssuedDisp":"January 22, 2021","dateIssuedKey":"2021"}],"name":{"displayForm":["Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet"]}} | ||
| SRT | |a QUINTAIROSEARLYPROGN2220 | ||