Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients
Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONM...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 22, 2021
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| In: |
PLOS ONE
Year: 2021, Volume: 16, Issue: 1, Pages: 1-20 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0245880 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0245880 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245880 
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| Author Notes: | Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet |
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| 245 | 1 | 0 | |a Early prognostic performance of miR155-5p monitoring for the risk of rejection |b Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients |c Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet |
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| 520 | |a Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR. | ||
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