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Mechanisms of stroke protection by physical activity

Regular physical activity is associated with a decrease of cerebrovascular and cardiovascular events, which may relate to enhanced endothelium-dependent vasodilation. Here, we provide evidence that physical activity protects against ischemic stroke via mechanisms related to the upregulation of endot...

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Main Authors: Endres, Matthias (Author) , Gertz, Karen (Author) , Lindauer, Ute (Author) , Katchanov, Juri (Author) , Schultze, Jörg (Author) , Schröck, Helmut (Author) , Nickenig, Georg (Author) , Kuschinsky, Wolfgang (Author) , Dirnagl, Ulrich (Author) , Laufs, Ulrich (Author)
Format: Article (Journal)
Language:English
Published: [2003]
In: Annals of neurology
Year: 2003, Volume: 54, Issue: 5, Pages: 582-590
ISSN:1531-8249
DOI:10.1002/ana.10722
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/ana.10722
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.10722
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Author Notes:Matthias Endres, Karen Gertz, Ute Lindauer, Juri Katchanov, Jörg Schultze, Helmut Schröck, Georg Nickenig, Wolfgang Kuschinsky, Ulrich Dirnagl, and Ulrich Laufs
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Summary:Regular physical activity is associated with a decrease of cerebrovascular and cardiovascular events, which may relate to enhanced endothelium-dependent vasodilation. Here, we provide evidence that physical activity protects against ischemic stroke via mechanisms related to the upregulation of endothelial nitric oxide synthase (eNOS) in the vasculature. Voluntary training on running wheels or exercise on a treadmill apparatus for 3 weeks, respectively, reduced cerebral infarct size and functional deficits, improved endothelium-dependent vasorelaxation, and augmented cerebral blood flow in wild-type mice. The neuroprotective effects of physical training were completely absent in eNOS-deficient mice, indicating that the enhanced eNOS activity by physical training was the predominant mechanism by which this modality protects against cerebral injury. Our results suggest that physical activity not only decreases stroke risk, but also provides a prophylactic treatment strategy for increasing blood flow and reducing brain injury during cerebral ischemia.
Item Description:First published: 16 September 2003
Gesehen am 05.05.2021
Physical Description:Online Resource
ISSN:1531-8249
DOI:10.1002/ana.10722

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