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Prenatal alcohol exposure and the facial phenotype in adolescents: a study based on meconium ethyl glucuronide

Here, we explore the effects of prenatal alcohol exposure (PAE) in adolescence. We investigated associations between meconium ethyl glucoronide (EtG) and facial malformation. For 129 children (66/63 male/female; M = 13.3, SD = 0.32, 12-14 years), PAE was implemented by newborn meconium EtG and mater...

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Main Authors: Maschke, Janina (Author) , Roetner, Jakob (Author) , Goecke, Tamme W. (Author) , Fasching, Peter A. (Author) , Beckmann, Matthias W. (Author) , Kratz, Oliver Rudolf (Author) , Moll, Gunther H. (Author) , Lenz, Bernd (Author) , Kornhuber, Johannes (Author) , Eichler, Anna (Author)
Format: Article (Journal)
Language:English
Published: 25 January 2021
In: Brain Sciences
Year: 2021, Volume: 11, Issue: 2, Pages: 1-20
ISSN:2076-3425
DOI:10.3390/brainsci11020154
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/brainsci11020154
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2076-3425/11/2/154
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Author Notes:Janina Maschke, Jakob Roetner, Tamme W. Goecke, Peter A. Fasching, Matthias W. Beckmann, Oliver Kratz, Gunther H. Moll, Bernd Lenz, Johannes Kornhuber, Anna Eichler and IMAC-Mind-Consortium
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Summary:Here, we explore the effects of prenatal alcohol exposure (PAE) in adolescence. We investigated associations between meconium ethyl glucoronide (EtG) and facial malformation. For 129 children (66/63 male/female; M = 13.3, SD = 0.32, 12-14 years), PAE was implemented by newborn meconium EtG and maternal self-reports during the third trimester. Cognitive development was operationalized by standardized scores (WISC V). The EtG cut-off values were set at ≥10 ng/g (n = 32, 24.8% EtG10+) and ≥112 ng/g (n = 20, 15.5% EtG112+). The craniofacial shape was measured using FAS Facial Photographic Analysis Software. EtG10+− and EtG112+-affected children exhibited a shorter palpebral fissure length (p = 0.031/p = 0.055). Lip circularity was smaller in EtG112+-affected children (p = 0.026). Maternal self-reports were not associated (p > 0.164). Lip circularity correlated with fluid reasoning (EtG10+ p = 0.031; EtG112+ p = 0.298) and working memory (EtG10+ p = 0.084; EtG112+ p = 0.144). The present study demonstrates visible effects of the facial phenotype in exposed adolescents. Facial malformation was associated with a child’s cognitive performance in the alcohol-exposed group. The EtG biomarker was a better predictor than maternal self-reports.
Item Description:Gesehen am 05.05.2021
Physical Description:Online Resource
ISSN:2076-3425
DOI:10.3390/brainsci11020154

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