Entry of phenuiviruses into mammalian host cells
Phenuiviridae is a large family of arthropod-borne viruses with over 100 species worldwide. Several cause severe diseases in both humans and livestock. Global warming and the apparent geographical expansion of arthropod vectors are good reasons to seriously consider these viruses potential agents of...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 February 2021
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| In: |
Viruses
Year: 2021, Volume: 13, Issue: 2, Pages: 1-16 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13020299 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/v13020299 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4915/13/2/299 
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| Author Notes: | Jana Koch, Qilin Xin, Nicole D. Tischler and Pierre-Yves Lozach |
| Summary: | Phenuiviridae is a large family of arthropod-borne viruses with over 100 species worldwide. Several cause severe diseases in both humans and livestock. Global warming and the apparent geographical expansion of arthropod vectors are good reasons to seriously consider these viruses potential agents of emerging diseases. With an increasing frequency and number of epidemics, some phenuiviruses represent a global threat to public and veterinary health. This review focuses on the early stage of phenuivirus infection in mammalian host cells. We address current knowledge on each step of the cell entry process, from virus binding to penetration into the cytosol. Virus receptors, endocytosis, and fusion mechanisms are discussed in light of the most recent progress on the entry of banda-, phlebo-, and uukuviruses, which together constitute the three prominent genera in the Phenuiviridae family. |
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| Item Description: | Gesehen am 06.05.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13020299 |