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Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communication within the tu...

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Main Authors: Marquard, Simone (Author) , Thomann, Stefan (Author) , Weiler, Sofia Maria Elisabeth (Author) , Bissinger, Michaela (Author) , Lutz, Teresa (Author) , Sticht, Carsten (Author) , Tóth, Marcell (Author) , Torre, Carolina de la (Author) , Gretz, Norbert (Author) , Straub, Beate Katharina (Author) , Marquardt, Jens (Author) , Schirmacher, Peter (Author) , Breuhahn, Kai (Author)
Format: Article (Journal)
Language:English
Published: 23 October 2020
In: Cell communication and signaling
Year: 2020, Volume: 18, Pages: 1-15
ISSN:1478-811X
DOI:10.1186/s12964-020-00634-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-020-00634-6
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Author Notes:Simone Marquard, Stefan Thomann, Sofia M. E. Weiler, Michaela Bissinger, Teresa Lutz, Carsten Sticht, Marcell Tóth, Carolina de la Torre, Norbert Gretz, Beate K. Straub, Jens Marquardt, Peter Schirmacher and Kai Breuhahn
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Summary:Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communication within the tumor microenvironment is not well understood.
Item Description:Gesehen am 10.05.2021
Physical Description:Online Resource
ISSN:1478-811X
DOI:10.1186/s12964-020-00634-6

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