Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis
Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communication within the tu...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 October 2020
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| In: |
Cell communication and signaling
Year: 2020, Volume: 18, Pages: 1-15 |
| ISSN: | 1478-811X |
| DOI: | 10.1186/s12964-020-00634-6 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-020-00634-6
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| Author Notes: | Simone Marquard, Stefan Thomann, Sofia M. E. Weiler, Michaela Bissinger, Teresa Lutz, Carsten Sticht, Marcell Tóth, Carolina de la Torre, Norbert Gretz, Beate K. Straub, Jens Marquardt, Peter Schirmacher and Kai Breuhahn |
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| 520 | |a Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communication within the tumor microenvironment is not well understood. | ||
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