Associations between NT-proBNP and psychosocial factors in patients with chronic systolic heart failure
Objective - B-type natriuretic peptides (BNPs) and their biologically inactive N-terminal parts, namely, NT-proBNPs, are used for diagnostic and prognostic purposes in patients with chronic heart failure (CHF). Associations of BNPs and NT-proBNPs with emotional factors may exist. As depressive and a...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 February 2021
|
| In: |
Journal of psychosomatic research
Year: 2021, Volume: 143, Pages: 1-7 |
| ISSN: | 1879-1360 |
| DOI: | 10.1016/j.jpsychores.2021.110385 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jpsychores.2021.110385 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022399921000301 
|
| Author Notes: | Thomas Müller-Tasch, Katja Krug, Frank Peters-Klimm |
| Summary: | Objective - B-type natriuretic peptides (BNPs) and their biologically inactive N-terminal parts, namely, NT-proBNPs, are used for diagnostic and prognostic purposes in patients with chronic heart failure (CHF). Associations of BNPs and NT-proBNPs with emotional factors may exist. As depressive and anxious comorbidities and decreases in quality of life (QoL) are common in CHF patients, we explored the associations between NT-proBNP and depression, anxiety, and QoL in patients with CHF using cross-sectional and longitudinal analyses. - Methods - We used baseline and one-year follow-up NT-proBNP measurements and sociodemographic and clinical data from 180 patients with systolic CHF from a case management study. Depression was assessed with the Patient Health Questionnaire 9 (PHQ-9), anxiety was assessed with the Generalized Anxiety Disorder Scale 7 (GAD-7), and QoL was determined using the Short Form 36 (SF-36) health survey. - Results - Univariate correlation analyses showed significant negative associations between NT-proBNP and the scores of four out of eight QoL domains (range: r = −0.159 to −0.285, p = .042 to 0.001) of the SF-36 but not between NT-proBNP and depression and anxiety scores. In cross-sectional and longitudinal multivariate regression analyses, no significant associations between NT-proBNP and psychometric variables were found. - Conclusion - In patients with stable, chronic systolic heart failure, only weak relations between NT-proBNP and QoL exist, but no relations between NT-proBNP and depression and anxiety were found. These findings are placed in the current research context of this topic. Implications for future experimental studies are discussed. |
|---|---|
| Item Description: | Gesehen am 11.05.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1879-1360 |
| DOI: | 10.1016/j.jpsychores.2021.110385 |