Buchumschlag

Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin

Erythropoietin (EPO) and its receptor are expressed in the brain, and one of its roles appears to be neuroprotection. This study investigates whether chronic overexpression of EPO changes brain mRNA expression in the brains of transgenic mice. Therefore, cerebral mRNA expression was investigated in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Maurer, Martin H. (VerfasserIn) , Frietsch, Thomas (VerfasserIn) , Waschke, Klaus F. (VerfasserIn) , Kuschinsky, Wolfgang (VerfasserIn) , Gassmann, Max (VerfasserIn) , Schneider, Armin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2002]
In: Neuroscience letters
Year: 2002, Jahrgang: 327, Heft: 3, Pages: 181-184
ISSN:1872-7972
DOI:10.1016/S0304-3940(02)00425-1
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3940(02)00425-1
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304394002004251
Volltext
Verfasserangaben:Martin H Maurer, Thomas Frietsch, Klaus F Waschke, Wolfgang Kuschinsky, Max Gassmann, Armin Schneider
Beschreibung
Zusammenfassung:Erythropoietin (EPO) and its receptor are expressed in the brain, and one of its roles appears to be neuroprotection. This study investigates whether chronic overexpression of EPO changes brain mRNA expression in the brains of transgenic mice. Therefore, cerebral mRNA expression was investigated in transgenic mice overexpressing EPO. Microarray analysis revealed an upregulation (2.8- to 3.6-fold) of N-acetylglucosamine-6-O-sulfotransferase (prolongation of the EPO effect), a translocase of the inner mitochondrial membrane (mitochondrial matrix import of nuclear encoded proteins), a mitochondrial ribosomal protein (mitochondrial protein translation), and a peroxisomal biogenesis factor (formation of peroxisomes). In conclusion, components of oxidative metabolism pathways were activated at the level of transcription which could be related to neuroprotective effects of EPO or could indicate compromised tissue.
Beschreibung:Gesehen am 12.05.2021
Beschreibung:Online Resource
ISSN:1872-7972
DOI:10.1016/S0304-3940(02)00425-1

Ähnliche Einträge