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Assessment of skeletal muscle microcirculation in type 2 diabetes mellitus using dynamic contrast-enhanced ultrasound: a pilot study

Purpose:To investigate muscular micro-perfusion by employing dynamic contrast-enhanced ultrasound (CEUS) and performing transient arterial occlusion in patients with type 2 diabetes mellitus (DM-2).Methods:Twenty DM-2 patients (mean age, 58 ± 8.6 years; duration of diabetes, 15.4 ± 12.1 years) and 2...

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Hauptverfasser: Amarteifio, Erick (VerfasserIn) , Wormsbecher, Stephanie (VerfasserIn) , Demirel, Serdar (VerfasserIn) , Krix, Martin (VerfasserIn) , Braun, Simone (VerfasserIn) , Rehnitz, Christoph (VerfasserIn) , Delorme, Stefan (VerfasserIn) , Kauczor, Hans-Ulrich (VerfasserIn) , Weber, Marc-André (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 21, 2013
In: Diabetes & vascular disease research
Year: 2013, Jahrgang: 10, Heft: 5, Pages: 468-470
ISSN:1752-8984
DOI:10.1177/1479164113484165
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/1479164113484165
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Verfasserangaben:Erick Amarteifio, Stephanie Wormsbecher, Serdar Demirel, Martin Krix, Simone Braun, Christoph Rehnitz, Stefan Delorme, Hans-Ulrich Kauczor and Marc-André Weber
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Zusammenfassung:Purpose:To investigate muscular micro-perfusion by employing dynamic contrast-enhanced ultrasound (CEUS) and performing transient arterial occlusion in patients with type 2 diabetes mellitus (DM-2).Methods:Twenty DM-2 patients (mean age, 58 ± 8.6 years; duration of diabetes, 15.4 ± 12.1 years) and 20 healthy volunteers (mean age, 54 ± 5.4 years) participated. CEUS was applied to the calf, while 4.8 mL of SonoVue? was injected intravenously. At the thigh level, arterial occlusion (60 s) was performed. CEUS parameters (tmax, max, AUCpost and m) were evaluated and Pearson-product-moment correlation coefficients were computed.Results:A moderate negative correlation of HbA1c and max was established (?0.53). Max in patients with DM-2 >10 years was 79.89 ± 37.4. Max in patients with DM-2 duration <10 years was 137.62 ± 71.72 (p = 0.04). AUCpost in patients with DM-2 duration >10 years was 3924.01 ± 1630.52. AUCpost in patients with DM-2 duration <10 years was 6453.59 ± 3206.23 (p = 0.04).Conclusion:Patients with long history of DM-2 present with impaired muscular perfusion. CEUS and transient arterial occlusion may provide appropriate methods for semi-quantitative evaluation of muscular micro-perfusion in patients with DM-2.
Beschreibung:Gesehen am 12.05.2021
Beschreibung:Online Resource
ISSN:1752-8984
DOI:10.1177/1479164113484165

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