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Impact of zinc- or copper-doped mesoporous bioactive glass nanoparticles on the osteogenic differentiation and matrix formation of mesenchymal stromal cells

Mesoporous bioactive glass nanoparticles (MBGNs) have gained relevance in bone tissue engineering, especially since they can be used as vectors for therapeutically active ions like zinc (Zn) or copper (Cu). In this study, the osteogenic properties of the ionic dissolution products (IDPs) of undoped...

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Main Authors: Westhauser, Fabian (Author) , Decker, Simon (Author) , Nawaz, Qaisar (Author) , Rehder, Felix (Author) , Wilkesmann, Sebastian (Author) , Moghaddam-Alvandi, Arash (Author) , Kunisch, Elke (Author) , Boccaccini, Aldo R. (Author)
Format: Article (Journal)
Language:English
Published: 9 April 2021
In: Materials
Year: 2021, Volume: 14, Issue: 8, Pages: 1-13
ISSN:1996-1944
DOI:10.3390/ma14081864
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ma14081864
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1996-1944/14/8/1864
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Author Notes:Fabian Westhauser, Simon Decker, Qaisar Nawaz, Felix Rehder, Sebastian Wilkesmann, Arash Moghaddam, Elke Kunisch and Aldo R. Boccaccini
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Summary:Mesoporous bioactive glass nanoparticles (MBGNs) have gained relevance in bone tissue engineering, especially since they can be used as vectors for therapeutically active ions like zinc (Zn) or copper (Cu). In this study, the osteogenic properties of the ionic dissolution products (IDPs) of undoped MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs doped with 5 mol% of either Zn (5Zn-MBGNs) or Cu (5Cu-MBGNs; compositions in mol%: 70 SiO2, 25 CaO, 5 ZnO/CuO) on human bone marrow-derived mesenchymal stromal cells were evaluated. Extracellular matrix (ECM) formation and calcification were assessed, as well as the IDPs’ influence on viability, cellular osteogenic differentiation and the expression of genes encoding for relevant members of the ECM. The IDPs of undoped MBGNs and 5Zn-MBGNs had a comparable influence on cell viability, while it was enhanced by IDPs of 5Cu-MBGNs compared to the other MBGNs. IDPs of 5Cu-MBGNs had slightly positive effects on ECM formation and calcification. 5Zn-MBGNs provided the most favorable pro-osteogenic properties since they increased not only cellular osteogenic differentiation and ECM-related gene expression but also ECM formation and calcification significantly. Future studies should analyze other relevant properties of MBGNs, such as their impact on angiogenesis.
Item Description:Gesehen am 01.02.2022
Physical Description:Online Resource
ISSN:1996-1944
DOI:10.3390/ma14081864

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