B cell-regulated immune responses in tumor models and cancer patients
The essential role played by T cells in anticancer immunity is widely accepted. The immunosuppressive functions of regulatory T cells are central for tumor progression and have been endowed with a robust predictive value. Increasing evidence indicates that also B cells have a crucial part in the reg...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 Jul 2013
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| In: |
OncoImmunology
Year: 2013, Volume: 2, Issue: 7 |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.25443 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4161/onci.25443
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| Author Notes: | Carlo Fremd, Florian Schuetz, Christof Sohn, Philipp Beckhove & Christoph Domschke |
| Summary: | The essential role played by T cells in anticancer immunity is widely accepted. The immunosuppressive functions of regulatory T cells are central for tumor progression and have been endowed with a robust predictive value. Increasing evidence indicates that also B cells have a crucial part in the regulation of T-cell responses against tumors. Although experiments reporting the production of natural antitumor antibodies and the induction of cytotoxic immune responses have revealed a tumor-protective function for B cells, other findings suggest that B cells may also exert tumor-promoting functions, resulting in a controversial picture. Here, we review recent evidence on the interactions between B and T cells in murine models and cancer patients and their implications for cancer immunology. |
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| Item Description: | Gesehen am 17.05.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2162-402X |
| DOI: | 10.4161/onci.25443 |