Blood CD3-(CD56 or 16)+ natural killer cell distributions are heterogeneous in healthy adults and suppressed by azathioprine in patients with ANCA-associated vasculitides
Cytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune diseases. Still, basic blood NK cell parameters are poorly defined. The aims of this study were 1) to establish reference values of NK cell counts and percentages...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 April 2021
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| In: |
BMC immunology
Year: 2021, Volume: 22, Pages: 1-13 |
| ISSN: | 1471-2172 |
| DOI: | 10.1186/s12865-021-00416-w |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12865-021-00416-w
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| Author Notes: | Wolfgang Merkt, Ulrich Salzer, Jens Thiel, Ilona Jandova, Raoul Bergner, Ana C. Venhoff and Nils Venhoff |
| Summary: | Cytotoxic Natural Killer (NK) cells are increasingly recognized as a powerful tool to induce targeted cell death in cancer and autoimmune diseases. Still, basic blood NK cell parameters are poorly defined. The aims of this study were 1) to establish reference values of NK cell counts and percentages in healthy adults; 2) to describe these parameters in the prototype autoimmune disease group ANCA-associated vasculitis (AAV); and 3) to investigate whether NK cell counts and percentages may be used as activity biomarkers in the care of AAV patients, as suggested by a preceding study. |
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| Item Description: | Gesehen am 17.05.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1471-2172 |
| DOI: | 10.1186/s12865-021-00416-w |