Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m)

To investigate the effect of acute hypoxia and concomitant changes in portal blood flow on the disposition of drugs mainly metabolized by the cytochrome P450 enzymes (CYP) 3A4 (verapamil) and CYP1A2 (theophylline).

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Bibliographic Details
Main Authors:	Streit, Michael (Author) , Göggelmann, Christoph (Author) , Dehnert, Christoph (Author) , Burhenne, Jürgen (Author) , Riedel, Klaus-Dieter (Author) , Menold, Elmar (Author) , Mikus, Gerd (Author) , Bärtsch, Peter (Author) , Haefeli, Walter E. (Author)
Format:	Article (Journal)
Language:	English
Published:	04 February 2005
In:	European journal of clinical pharmacology Year: 2005, Volume: 61, Issue: 1, Pages: 39-46
ISSN:	1432-1041
DOI:	10.1007/s00228-004-0886-1
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00228-004-0886-1
Author Notes:	Michael Streit, Christoph Göggelmann, Christoph Dehnert, Jürgen Burhenne, Klaus-Dieter Riedel, Elmar Menold, Gerd Mikus, Peter Bärtsch, Walter E. Haefeli

Description
Summary:	To investigate the effect of acute hypoxia and concomitant changes in portal blood flow on the disposition of drugs mainly metabolized by the cytochrome P450 enzymes (CYP) 3A4 (verapamil) and CYP1A2 (theophylline).
Item Description:	Gesehen am 18.05.2021 Im Titel ist "450" tiefgestellt
Physical Description:	Online Resource
ISSN:	1432-1041
DOI:	10.1007/s00228-004-0886-1