Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect
A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels an...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 September 2004
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| In: |
Clinical infectious diseases
Year: 2004, Volume: 39, Issue: 6, Pages: e49-e52 |
| ISSN: | 1537-6591 |
| DOI: | 10.1086/423275 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1086/423275
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| Author Notes: | Y. Alkan, W.E. Haefeli, J. Burhenne, J. Stein, I. Yaniv, and I. Shalit |
| Summary: | A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non—concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment. |
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| Item Description: | Gesehen am 19.05.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1537-6591 |
| DOI: | 10.1086/423275 |