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Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect

A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels an...

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Bibliographische Detailangaben
Hauptverfasser: Alkan, Yoav (VerfasserIn) , Haefeli, Walter E. (VerfasserIn) , Burhenne, Jürgen (VerfasserIn) , Stein, J. (VerfasserIn) , Yaniv, I. (VerfasserIn) , Shalit, Itamar (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 September 2004
In: Clinical infectious diseases
Year: 2004, Jahrgang: 39, Heft: 6, Pages: e49-e52
ISSN:1537-6591
DOI:10.1086/423275
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1086/423275
Volltext
Verfasserangaben:Y. Alkan, W.E. Haefeli, J. Burhenne, J. Stein, I. Yaniv, and I. Shalit
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Zusammenfassung:A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non—concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.
Beschreibung:Gesehen am 19.05.2021
Beschreibung:Online Resource
ISSN:1537-6591
DOI:10.1086/423275

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