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IGF-1 facilitates extinction of conditioned fear

Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing and synaptic transmission in many areas of the central nervous system, its signaling and consequences on excitability, synaptic...

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Main Authors: Maglio, Laura E. (Author) , Noriega-Prieto, José A (Author) , Maroto, Irene B (Author) , Martín-Cortecero, Jesús (Author) , Muñoz-Callejas, Antonio (Author) , Callejo-Móstoles, Marta (Author) , Fernández de Sevilla, David (Author)
Format: Article (Journal)
Language:English
Published: 01 April 2021
In: eLife
Year: 2021, Volume: 10, Pages: 1-20
ISSN:2050-084X
DOI:10.7554/eLife.67267
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.67267
Verlag, lizenzpflichtig, Volltext: https://elifesciences.org/articles/67267
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Author Notes:Laura E Maglio, José A Noriega-Prieto, Irene B Maroto, Jesús Martin-Cortecero, Antonio Muñoz-Callejas, Marta Callejo-Móstoles, David Fernández de Sevilla
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Summary:Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing and synaptic transmission in many areas of the central nervous system, its signaling and consequences on excitability, synaptic plasticity, and animal behavior dependent on the prefrontal cortex remain unexplored. Here, we show that IGF-1 induces a long-lasting depression of the medium and slow post-spike afterhyperpolarization (mAHP and sAHP), increasing the excitability of layer 5 pyramidal neurons of the rat infralimbic cortex. Besides, IGF-1 mediates a presynaptic long-term depression of both inhibitory and excitatory synaptic transmission in these neurons. The net effect of this IGF-1-mediated synaptic plasticity is a long-term potentiation of the postsynaptic potentials. Moreover, we demonstrate that IGF-1 favors the fear extinction memory. These results show novel functional consequences of IGF-1 signaling, revealing IGF-1 as a key element in the control of the fear extinction memory.
Item Description:Gesehen am 26.05.2021
Physical Description:Online Resource
ISSN:2050-084X
DOI:10.7554/eLife.67267

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