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Inspired oxygen fraction after cardiopulmonary bypass: effects on pulmonary function with regard to endothelin-1 concentrations and venous admixture

Twenty consecutive patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were allocated at random to group 1 (n=10, high inspired oxygen fraction (FIO2) after CPB), or group 2 (n=10, moderate FIO2 after CPB). The effects of each FIO2 on arterial and mixed venous concentrations of end...

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Main Authors: Reber, Adrian (Author) , Budmiger, B. (Author) , Wenk, Markus (Author) , Haefeli, Walter E. (Author) , Wolff, T. (Author) , Bein, Thomas (Author) , Skarvan, K. (Author)
Format: Article (Journal)
Language:English
Published: 2000
In: British journal of anaesthesia
Year: 2000, Volume: 84, Issue: 5, Pages: 565-570
ISSN:1471-6771
DOI:10.1093/bja/84.5.565
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/bja/84.5.565
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0007091217380200
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Author Notes:A. Reber, B. Budmiger, M. Wenk, W.E. Haefeli, T. Wolff, T. Bein and K. Skarvan
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Summary:Twenty consecutive patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were allocated at random to group 1 (n=10, high inspired oxygen fraction (FIO2) after CPB), or group 2 (n=10, moderate FIO2 after CPB). The effects of each FIO2 on arterial and mixed venous concentrations of endothelin-1 (ET-1) and its precursor, Big ET-1, were measured. Venous admixture was calculated to assess the efficiency of pulmonary gas exchange. Patients whose lungs had been ventilated with a FIO2 of 1.0 (exposure time 70 min) after weaning from the CPB machine had significantly greater arterial and mixed venous Big ET-1 concentrations and venous admixture than patients whose lungs were ventilated with a FIO2 of 0.35. In contrast, ET-1 concentrations in the two groups were not significantly different. A reduction of FIO2 from 1.0 to 0.6 reduced venous admixture without lowering endothelial peptide concentrations. On the first postoperative day all peptide concentrations were similar in the two groups, whereas venous admixture remained non-significantly higher in group 1. A short period of high FIO2 immediately after CPB increases endothelin concentrations and pulmonary venous admixture.
Item Description:Online 13 December 2017
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Physical Description:Online Resource
ISSN:1471-6771
DOI:10.1093/bja/84.5.565

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