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Leptomeningeal carcinomatosis: a clinical dilemma in neuroendocrine neoplasms

Central nervous system (CNS) involvement by paraneoplastic syndromes, brain metastases, or leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms (NEN) has only been described in individual case reports. We evaluated patients with LC in four neuroendocrine tumor (NET) centers (...

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Bibliographic Details
Main Authors: Apostolidis, Leonidas (Author) , Schrader, Jörg (Author) , Jann, Henning (Author) , Rinke, Anja (Author) , Krug, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: 28 March 2021
In: Biology
Year: 2021, Volume: 10, Issue: 4, Pages: 1-11
ISSN:2079-7737
DOI:10.3390/biology10040277
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/biology10040277
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2079-7737/10/4/277
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Author Notes:Leonidas Apostolidis, Jörg Schrader, Henning Jann, Anja Rinke and Sebastian Krug
Description
Summary:Central nervous system (CNS) involvement by paraneoplastic syndromes, brain metastases, or leptomeningeal carcinomatosis (LC) in patients with neuroendocrine neoplasms (NEN) has only been described in individual case reports. We evaluated patients with LC in four neuroendocrine tumor (NET) centers (Halle/Saale, Hamburg, Heidelberg, and Marburg) and characterized them clinically. In the study, 17 patients with a LC were defined with respect to diagnosis, clinic, and therapy. The prognosis of a LC is very poor, with 10 months in median overall survival (mOS). This is reflected by an even worse course in neuroendocrine carcinoma (NEC) G3 Ki-67 >55%, with a mOS of 2 months. Motor and sensory deficits together with vigilance abnormalities were common symptoms. In most cases, targeted radiation or temozolomide therapy was used against the LC. LC appears to be similarly devastating to brain metastases in NEN patients. Therefore, the indication for CNS imaging should be discussed in certain cases.
Item Description:Gesehen am 26.05.2021
Physical Description:Online Resource
ISSN:2079-7737
DOI:10.3390/biology10040277

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