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Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities

Objectives: To evaluate the in vivo effect of xanthine oxidase (XO) inhibition by allopurinol on the determination of polymorphic N-acetyltransferase 2 (NAT2) and cytochrome P450 1A2 (CYP1A2) with urinary caffeine metabolic ratios.

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Bibliographic Details
Main Authors: Fuchs, P. (Author) , Haefeli, Walter E. (Author) , Ledermann, H. R. (Author) , Wenk, Markus (Author)
Format: Article (Journal)
Language:English
Published: January 1999
In: European journal of clinical pharmacology
Year: 1999, Volume: 54, Issue: 11, Pages: 869-876
ISSN:1432-1041
DOI:10.1007/s002280050569
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s002280050569
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Author Notes:P. Fuchs, W. E. Haefeli, H. R. Ledermann, M. Wenk
Description
Summary:Objectives: To evaluate the in vivo effect of xanthine oxidase (XO) inhibition by allopurinol on the determination of polymorphic N-acetyltransferase 2 (NAT2) and cytochrome P450 1A2 (CYP1A2) with urinary caffeine metabolic ratios.
Item Description:Gesehen am 27.05.2021
Physical Description:Online Resource
ISSN:1432-1041
DOI:10.1007/s002280050569

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