Changes in the serum proteome of patients with sepsis and septic shock
BACKGROUND: - Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28. - METHODS: - We applied proteomic technology to serum samples of patients with sepsi...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[December 2006]
|
| In: |
Anesthesia & analgesia
Year: 2006, Jahrgang: 103, Heft: 6, Pages: 1522-1526 |
| ISSN: | 1526-7598 |
| DOI: | 10.1213/01.ane.0000242533.59457.70 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1213/01.ane.0000242533.59457.70 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/anesthesia-analgesia/Fulltext/2006/12000/Changes_in_the_Serum_Proteome_of_Patients_with.36.aspx 
|
| Verfasserangaben: | Armin Kalenka, Robert E. Jr Feldmann, Kevin Otero, Martin H. Maurer, Klaus F. Waschke, Fritz Fiedler |
| Zusammenfassung: | BACKGROUND: - Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28. - METHODS: - We applied proteomic technology to serum samples of patients with sepsis and septic shock. Serum samples from 18 patients with sepsis and septic shock were obtained during the first 12 h after diagnosis of septic shock. Patients were grouped into SURV and NON-SURV on day 28. - RESULTS: - Seven patients survived and 11 patients died. Using proteome analysis, two-dimensional gel electrophoresis detected more than 200 spots per gel. A differential protein expression was discovered between SURV and NON-SURV, whereby protein alterations not yet described in sepsis were revealed. - CONCLUSIONS: - Our results show that proteomic profiling is a useful approach for detecting protein expression dynamics in septic patients, and may bring us closer to achieving a comprehensive molecular profiling compared with genetic studies alone. |
|---|---|
| Beschreibung: | Gesehen am 28.05.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1526-7598 |
| DOI: | 10.1213/01.ane.0000242533.59457.70 |