Cover Image

Changes in the serum proteome of patients with sepsis and septic shock

BACKGROUND: - Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28. - METHODS: - We applied proteomic technology to serum samples of patients with sepsi...

Full description

Saved in:
Bibliographic Details
Main Authors: Kalenka, Armin (Author) , Feldmann, Robert Enrico (Author) , Otero-Scheibelhofer, Kevin (Author) , Maurer, Martin H. (Author) , Waschke, Klaus F. (Author) , Fiedler, Fritz (Author)
Format: Article (Journal)
Language:English
Published: [December 2006]
In: Anesthesia & analgesia
Year: 2006, Volume: 103, Issue: 6, Pages: 1522-1526
ISSN:1526-7598
DOI:10.1213/01.ane.0000242533.59457.70
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1213/01.ane.0000242533.59457.70
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/anesthesia-analgesia/Fulltext/2006/12000/Changes_in_the_Serum_Proteome_of_Patients_with.36.aspx
Get full text
Author Notes:Armin Kalenka, Robert E. Jr Feldmann, Kevin Otero, Martin H. Maurer, Klaus F. Waschke, Fritz Fiedler
Description
Summary:BACKGROUND: - Sepsis is still the leading cause of death in the intensive care unit. Our goal was to elucidate potential early differences in serum between survivors (SURV) and non-survivors (NON-SURV) on day 28. - METHODS: - We applied proteomic technology to serum samples of patients with sepsis and septic shock. Serum samples from 18 patients with sepsis and septic shock were obtained during the first 12 h after diagnosis of septic shock. Patients were grouped into SURV and NON-SURV on day 28. - RESULTS: - Seven patients survived and 11 patients died. Using proteome analysis, two-dimensional gel electrophoresis detected more than 200 spots per gel. A differential protein expression was discovered between SURV and NON-SURV, whereby protein alterations not yet described in sepsis were revealed. - CONCLUSIONS: - Our results show that proteomic profiling is a useful approach for detecting protein expression dynamics in septic patients, and may bring us closer to achieving a comprehensive molecular profiling compared with genetic studies alone.
Item Description:Gesehen am 28.05.2021
Physical Description:Online Resource
ISSN:1526-7598
DOI:10.1213/01.ane.0000242533.59457.70

Similar Items