Local transport kinetics of glucose during acute and chronic nicotine infusion in rat brains
Acute and chronic infusion of nicotine is known to result in a distinct increase in local cerebral glucose utilization (LCGU) in several brain structures. The present study addresses the question whether this increase in LCGU is paralleled by a local change in glucose transport in rat brain. Nicotin...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[1998]
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| In: |
Journal of neural transmission
Year: 1998, Jahrgang: 105, Heft: 8, Pages: 1017-1028 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s007020050109 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s007020050109
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| Verfasserangaben: | R. Duelli, R. Staudt, M.H. Maurer, and W. Kuschinsky |
| Zusammenfassung: | Acute and chronic infusion of nicotine is known to result in a distinct increase in local cerebral glucose utilization (LCGU) in several brain structures. The present study addresses the question whether this increase in LCGU is paralleled by a local change in glucose transport in rat brain. Nicotine was infused either acutely for 3 hours or chronically by osmotic minipumps for one week. Local rate constants for glucose transport were measured in brain cryosections using the 3-O-[14C]methylglucose method. Local rate constants K1 and k2 were lower in part of the brain structures during acute (−10% to −20%) and in nearly all structures during chronic (−39% to −41%) nicotine. The finding of a decreased glucose transport during chronic nicotine was confirmed by additional experiments of 3-O-[14C]methylglucose transfer in an epithelial cell culture. It is concluded that acute and chronic nicotine infusion results in decreased glucose transport although LCGU is either unchanged or increased. |
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| Beschreibung: | Gesehen am 28.05.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s007020050109 |