Comparing metabolomics profiles in various types of liquid biopsies among screening participants with and without advanced colorectal neoplasms
Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. We investigated and compared the metabolomics profile in blood, stool, and urine samples of screening colonoscopy participants and aimed to evaluate differences in meta...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 March 2021
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| In: |
Diagnostics
Year: 2021, Volume: 11, Issue: 3, Pages: 1-13 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11030561 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics11030561 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/11/3/561 
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| Author Notes: | Vanessa Erben, Gernot Poschet, Petra Schrotz-King and Hermann Brenner |
| Summary: | Analysis of metabolomics has been suggested as a promising approach for early detection of colorectal cancer and advanced adenomas. We investigated and compared the metabolomics profile in blood, stool, and urine samples of screening colonoscopy participants and aimed to evaluate differences in metabolite concentrations between people with advanced colorectal neoplasms and those without neoplasms. Various types of bio-samples (plasma, feces, and urine) from 400 participants of screening colonoscopy were investigated using the MxP® Quant 500 kit (Biocrates, Innsbruck, Austria). We detected a broad range of metabolites in blood, stool, and urine samples (504, 331, and 131, respectively). Significant correlations were found between concentrations in blood and stool, blood and urine, and stool and urine for 93, 154, and 102 metabolites, of which 68 (73%), 126 (82%), and 39 (38%) were positive correlations. We found significant differences between participants with and without advanced colorectal neoplasms for concentrations of 123, 49, and 28 metabolites in blood, stool and urine samples, respectively. We detected mostly positive correlations between metabolite concentrations in blood samples and urine or stool samples, and mostly negative correlations between urine and stool samples. Differences between subjects with and without advanced colorectal neoplasms were found for metabolite concentrations in each of the three bio-fluids. |
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| Item Description: | Gesehen am 01.06.2021 |
| Physical Description: | Online Resource |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11030561 |