Patterns of cortical activity and memory performance in Alzheimer’s disease
Background: %Declarative memory changes are the hallmark of Alzheimer’s disease, although their functional neuroanatomy is not restricted to a single structure. Factor analysis provides statistical methods for evaluating patterns of cerebral changes in regional glucose uptake. Methods:Thirty-three A...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 March 2001
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| In: |
Biological psychiatry
Year: 2001, Volume: 49, Issue: 5, Pages: 426-436 |
| ISSN: | 1873-2402 |
| DOI: | 10.1016/S0006-3223(00)00983-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0006-3223(00)00983-5 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006322300009835 
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| Author Notes: | Johannes Schröder, Monte S Buchsbaum, Lina Shihabuddin, Cheuk Tang, Tse-Chung Wei, Jacqueline Spiegel-Cohen, Erin A Hazlett, Lennart Abel, Christina Luu-Hsia, Tina M Ciaravolo, Deborah Marin, Kenneth L Davis |
| Summary: | Background: %Declarative memory changes are the hallmark of Alzheimer’s disease, although their functional neuroanatomy is not restricted to a single structure. Factor analysis provides statistical methods for evaluating patterns of cerebral changes in regional glucose uptake. Methods:Thirty-three Alzheimer’s patients and 33 age- and gender-matched control subjects were studied with magnetic resonance imaging and positron emission tomography with [18F] deoxyglucose. During the tracer-uptake period, subjects performed a serial verbal learning task. Cortical activity was measured in 32 regions of interest, four in each lobe on both hemispheres. Results:Factor analysis with varimax rotation identified seven factors explaining 80% of the variance (“parietal cortex,” “occipital cortex,” “right temporo-prefrontal areas,” “frontal cortex,” “motor strip,” “left temporal cortex,” and “posterior temporal cortex”). Relative to control subjects, Alzheimer’s patients showed significantly reduced values on the factors occipital cortex, right temporo-prefrontal areas, frontal cortex, and left temporal cortex. The factor temporo-prefrontal areas showed large differences between patients with good and poor performance, but little difference when control subjects were similarly divided. Conclusions:Findings suggest that Alzheimer’s disease is characterized by altered patterns of cortical activity, rather than deficits in a single location, and emphasize the importance of right temporo-prefrontal circuitry for understanding memory deficits. |
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| Item Description: | Gesehen am 02.06.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1873-2402 |
| DOI: | 10.1016/S0006-3223(00)00983-5 |