Buchumschlag

Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations

Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host...

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Hauptverfasser: Spierings, Eric (VerfasserIn) , Hendriks, Matthijs (VerfasserIn) , Absi, Léna (VerfasserIn) , Canossi, Angelica (VerfasserIn) , Chhaya, Sonal (VerfasserIn) , Crowley, John (VerfasserIn) , Dolstra, Harry (VerfasserIn) , Eliaou, Jean-François (VerfasserIn) , Ellis, Tom (VerfasserIn) , Enczmann, Jürgen (VerfasserIn) , Fasano, Maria E. (VerfasserIn) , Gervais, Thibaut (VerfasserIn) , Gorodezky, Clara (VerfasserIn) , Kircher, Brigitte (VerfasserIn) , Laurin, David (VerfasserIn) , Leffell, Mary S. (VerfasserIn) , Loiseau, Pascale (VerfasserIn) , Malkki, Mari (VerfasserIn) , Markiewicz, Miroslaw (VerfasserIn) , Martinetti, Miryam (VerfasserIn) , Maruya, Etsuko (VerfasserIn) , Mehra, Narinder (VerfasserIn) , Oguz, Fatma (VerfasserIn) , Oudshoorn, Machteld (VerfasserIn) , Pereira, Noemi (VerfasserIn) , Rani, Rajni (VerfasserIn) , Sergeant, Ruhena (VerfasserIn) , Thomson, Jackie (VerfasserIn) , Tran, Thuong Hien (VerfasserIn) , Turpeinen, Hannu (VerfasserIn) , Yang, Kuo-Liang (VerfasserIn) , Zunec, Renata (VerfasserIn) , Carrington, Mary (VerfasserIn) , de Knijff, Peter (VerfasserIn) , Goulmy, Els (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2007
In: PLoS Genetics
Year: 2007, Jahrgang: 3, Heft: 6, Pages: 1108-1119
ISSN:1553-7404
DOI:10.1371/journal.pgen.0030103
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pgen.0030103
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0030103
Volltext
Verfasserangaben:Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, Harry Dolstra, Jean-François Eliaou, Tom Ellis, Jürgen Enczmann, Maria E. Fasano, Thibaut Gervais, Clara Gorodezky, Brigitte Kircher, David Laurin, Mary S. Leffell, Pascale Loiseau, Mari Malkki, Miroslaw Markiewicz, Miryam Martinetti, Etsuko Maruya, Narinder Mehra, Fatma Oguz, Machteld Oudshoorn, Noemi Pereira, Rajni Rani, Ruhena Sergeant, Jackie Thomson, Thuong Hien Tran, Hannu Turpeinen, Kuo-Liang Yang, Renata Zunec, Mary Carrington, Peter de Knijff, Els Goulmy
Beschreibung
Zusammenfassung:Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.
Beschreibung:Gesehen am 02.06.2021
Beschreibung:Online Resource
ISSN:1553-7404
DOI:10.1371/journal.pgen.0030103

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