Cover Image

Borrelia burgdorferi regulates expression of complement regulator-acquiring surface protein 1 during the mammal-tick infection cycle

During the natural mammal-tick infection cycle, the Lyme disease spirochete Borrelia burgdorferi comes into contact with components of the alternative complement pathway. B. burgdorferi, like many other human pathogens, has evolved the immune evasion strategy of binding two host-derived fluid-phase...

Full description

Saved in:
Bibliographic Details
Main Authors: Lackum, Kate von (Author) , Miller, Jennifer C. (Author) , Bykowski, Tomasz (Author) , Riley, Sean P. (Author) , Woodman, Michael E. (Author) , Brade, Volker (Author) , Kraiczy, Peter (Author) , Stevenson, Brian (Author) , Wallich, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 2005
In: Infection and immunity
Year: 2005, Volume: 73, Issue: 11, Pages: 7398-7405
ISSN:1098-5522
DOI:10.1128/IAI.73.11.7398-7405.2005
Online Access:Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1128/IAI.73.11.7398-7405.2005
Get full text
Author Notes:Kate von Lackum, Jennifer C. Miller, Tomasz Bykowski, Sean P. Riley, Michael E. Woodman, Volker Brade, Peter Kraiczy, Brian Stevenson, and Reinhard Wallich
Description
Summary:During the natural mammal-tick infection cycle, the Lyme disease spirochete Borrelia burgdorferi comes into contact with components of the alternative complement pathway. B. burgdorferi, like many other human pathogens, has evolved the immune evasion strategy of binding two host-derived fluid-phase regulators of complement, factor H and factor H-like protein 1 (FHL-1). The borrelial complement regulator-acquiring surface protein 1 (CRASP-1) is a surface-exposed lipoprotein that binds both factor H and FHL-1. Analysis of CRASP-1 expression during the mammal-tick infectious cycle indicated that B. burgdorferi expresses this protein during mammalian infection, supporting the hypothesized role for CRASP-1 in immune evasion. However, CRASP-1 synthesis was repressed in bacteria during colonization of vector ticks. Analysis of cultured bacteria indicated that CRASP-1 is differentially expressed in response to changes in pH. Comparisons of CRASP-1 expression patterns with those of other infection-associated B. burgdorferi proteins, including the OspC, OspA, and Erp proteins, indicated that each protein is regulated through a unique mechanism.
Item Description:Gesehen am 07.06.2021
Physical Description:Online Resource
ISSN:1098-5522
DOI:10.1128/IAI.73.11.7398-7405.2005

Similar Items