Emerging insights into the ependymoma epigenome
Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic pro...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 February 2013
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| In: |
Brain pathology
Year: 2013, Volume: 23, Issue: 2, Pages: 206-209 |
| ISSN: | 1750-3639 |
| DOI: | 10.1111/bpa.12020 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/bpa.12020 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12020 
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| Author Notes: | Stephen C. Mack, Hendrik Witt, Xin Wang, Till Milde, Yuan Yao, Kelsey C. Bertrand, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor |
| Summary: | Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic profile. Candidate gene approaches looking at hypermethylated promoters and genome-wide epigenetic arrays suggest that DNA methylation may be critical to ependymoma pathogenesis. This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients. |
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| Item Description: | Gesehen am 11.06.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1750-3639 |
| DOI: | 10.1111/bpa.12020 |