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Autofluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw (MRONJ): a retrospective single-center study

Objective - Medication-related osteonecrosis of the jaw (MRONJ) has become a serious concern for patients under antiresorptive treatment, especially in the oncological setting. Different approaches have been described in the management of MRONJ, including innovative autofluorescence-guided surgery....

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Main Authors: Otto, Sven (Author) , Schnödt, Eva Maria (Author) , Haidari, Selgai (Author) , Brunner, Teresa Franziska (Author) , Aljohani, Suad (Author) , Mosleh, Mohamed (Author) , Ristow, Oliver (Author) , Tröltzsch, Matthias (Author) , Pautke, Christoph (Author) , Ehrenfeld, Michael (Author) , Fliefel, Riham (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Oral surgery, oral medicine, oral pathology and oral radiology
Year: 2021, Volume: 131, Issue: 5, Pages: 519-526
ISSN:2212-4411
DOI:10.1016/j.oooo.2020.10.018
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.oooo.2020.10.018
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2212440320312918
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Author Notes:Sven Otto, Eva Maria Schnödt, Selgai Haidari, Teresa Franziska Brunner, Suad Aljohani, Mohamed Mosleh, Oliver Ristow, Matthias Troeltzsch, Christoph Pautke, Michael Ehrenfeld and Riham Fliefel
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Summary:Objective - Medication-related osteonecrosis of the jaw (MRONJ) has become a serious concern for patients under antiresorptive treatment, especially in the oncological setting. Different approaches have been described in the management of MRONJ, including innovative autofluorescence-guided surgery. However, until now, there has been a lack of data regarding the outcome. In this study, we evaluated the efficacy of minimally invasive autofluorescence-guided resection in MRONJ. - Study Design - Seventy-five patients with 82 lesions were included in this retrospective, single-center study. All included patients were diagnosed with MRONJ according to the American Association of Oral and Maxillofacial Surgeons guidelines and underwent autofluorescence-guided surgery with a minimum follow-up of 3 months. The primary outcome was complete integrity of the mucosa and absence of bone exposure. - Results - The MRONJ stages were stage 0 (3.7%), stage 1 (3.7%), stage 2 (75.6%), and stage 3 (17%). Overall, complete mucosal healing of all lesions after the first surgery was 81.7% (67 of 82), whereas it was 90.2% (74 of 82) after revision surgery. - Conclusions - The study showed that autofluorescence-guided surgery is a safe and successful treatment option that can be considered for all stages of MRONJ.
Item Description:Online 26 October 2020
Gesehen am 14.06.2021
Physical Description:Online Resource
ISSN:2212-4411
DOI:10.1016/j.oooo.2020.10.018

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