Potential role of thioredoxin in immune responses in intestinal lamina propria T lymphocytes
Thioredoxin (TRX) is a ubiquitous oxidoreductase with strong co-cytokine, chemoattractant and anti-apoptotic activities. TRX expression was found to be particularly elevated in the intestinal mucosa, where its physiologic function is entirely unknown. Here, we demonstrate a high level of TRX express...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 January 2005
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| In: |
European journal of immunology
Year: 2005, Jahrgang: 35, Heft: 2, Pages: 408-417 |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.200424500 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/eji.200424500 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.200424500 
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| Verfasserangaben: | Bernd Sido, Thomas Giese, Frank Autschbach, Felix Lasitschka, Jutta Braunstein and Stefan C. Meuer |
| Zusammenfassung: | Thioredoxin (TRX) is a ubiquitous oxidoreductase with strong co-cytokine, chemoattractant and anti-apoptotic activities. TRX expression was found to be particularly elevated in the intestinal mucosa, where its physiologic function is entirely unknown. Here, we demonstrate a high level of TRX expression in lamina propria T cells (LP-T) as opposed to autologous peripheral blood T lymphocytes (PB-T). Addition of recombinant human TRX (rhTRX) to PB-T enhances TRX gene expression. This autoregulation involves the calcineurin signaling pathway, as rhTRX antagonizes the cyclosporine A (CsA)- and tacrolimus-mediated suppression of TRX gene expression. Similarly, rhTRX reverses the suppression of IL-2 mRNA production by CsA and enhances cytokine production preferentially in prestimulated cells. The differential TRX expression in LP-T versus PB-T may thus contribute to the high-level, CsA-resistant IL-2 production characteristic for CD2-stimulated LP-T. Inversely, inactivation of TRX in LP-T through inhibition of TRX reductase abolishes cytokine gene expression. TRX may play a key role in the specialized intestinal microenvironment in amplifying immediate immune responses of LP-T whenever appropriate costimulation of LP-T is provided. |
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| Beschreibung: | Gesehen am 14.06.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1521-4141 |
| DOI: | 10.1002/eji.200424500 |