Orthobunyaviruses: from virus binding to penetration into mammalian host cells
With over 80 members worldwide, Orthobunyavirus is the largest genus in the Peribunyaviridae family. Orthobunyaviruses (OBVs) are arthropod-borne viruses that are structurally simple, with a trisegmented, negative-sense RNA genome and only four structural proteins. OBVs are potential agents of emerg...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 May 2021
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| In: |
Viruses
Year: 2021, Volume: 13, Issue: 5, Pages: 1-12 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13050872 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/v13050872 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4915/13/5/872 
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| Author Notes: | Stefan Windhaber, Qilin Xin and Pierre-Yves Lozach |
| Summary: | With over 80 members worldwide, Orthobunyavirus is the largest genus in the Peribunyaviridae family. Orthobunyaviruses (OBVs) are arthropod-borne viruses that are structurally simple, with a trisegmented, negative-sense RNA genome and only four structural proteins. OBVs are potential agents of emerging and re-emerging diseases and overall represent a global threat to both public and veterinary health. The focus of this review is on the very first steps of OBV infection in mammalian hosts, from virus binding to penetration and release of the viral genome into the cytosol. Here, we address the most current knowledge and advances regarding OBV receptors, endocytosis, and fusion. |
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| Item Description: | Gesehen am 15.06.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13050872 |