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Novel serum markers of bone resorption: clinical assessment and comparison with established urinary indices

Although urinary measurements of collagen degradation provide valid estimates of bone resorption, their clinical application is hampered by pronounced analytical and biological variability. Therefore, immunoassays for the determination of such parameters in serum have been developed. In this study,...

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Main Authors: Woitge, Henning W. (Author) , Pecherstorfer, Martin (Author) , Li, Yuming (Author) , Keck, Andrea-V. (Author) , Horn, Eva (Author) , Ziegler, Reinhard (Author) , Seibel, Markus J. (Author)
Format: Article (Journal)
Language:English
Published: 1999
In: Journal of bone and mineral research
Year: 1999, Volume: 14, Issue: 5, Pages: 792-801
ISSN:1523-4681
DOI:10.1359/jbmr.1999.14.5.792
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1359/jbmr.1999.14.5.792
Verlag, lizenzpflichtig, Volltext: https://asbmr.onlinelibrary.wiley.com/doi/abs/10.1359/jbmr.1999.14.5.792
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Author Notes:Henning W. Woitge, Martin Pecherstorfer, Yuming Li, Andrea-V. Keck, Eva Horn, Reinhard Ziegler, and Markus J. Seibel
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Summary:Although urinary measurements of collagen degradation provide valid estimates of bone resorption, their clinical application is hampered by pronounced analytical and biological variability. Therefore, immunoassays for the determination of such parameters in serum have been developed. In this study, we assessed the performance of three new serum markers of bone turnover, i.e., C-terminal and N-terminal telopeptides of type I collagen (S-CTX and S-NTX) and bone sialoprotein.
Item Description:Elektronische Reproduktion der Druck-Ausgabe, 02 December 2009
Gesehen am 15.06.2021
Physical Description:Online Resource
ISSN:1523-4681
DOI:10.1359/jbmr.1999.14.5.792

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