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Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis

<h3>Objective</h3> <p>To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS).</p><h3>Methods</h3> <p>This single-centre, prospective, longitudinal study included the following pa...

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Main Authors: Verde, Federico (Author) , Steinacker, Petra (Author) , Weishaupt, Jochen H. (Author) , Kassubek, Jan (Author) , Oeckl, Patrick (Author) , Halbgebauer, Steffen (Author) , Tumani, Hayrettin (Author) , Arnim, Christine A. F. von (Author) , Dorst, Johannes (Author) , Feneberg, Emily (Author) , Mayer, Benjamin (Author) , Müller, Hans-Peter (Author) , Gorges, Martin (Author) , Rosenbohm, Angela (Author) , Volk, Alexander E. (Author) , Silani, Vincenzo (Author) , Ludolph, Albert C. (Author) , Otto, Markus (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Journal of neurology, neurosurgery, and psychiatry
Year: 2019, Volume: 90, Issue: 2, Pages: 157-164
ISSN:1468-330X
DOI:10.1136/jnnp-2018-318704
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jnnp-2018-318704
Verlag, lizenzpflichtig, Volltext: https://jnnp.bmj.com/content/90/2/157
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Author Notes:Federico Verde, Petra Steinacker, Jochen H Weishaupt, Jan Kassubek, Patrick Oeckl, Steffen Halbgebauer, Hayrettin Tumani, Christine AF von Arnim, Johannes Dorst, Emily Feneberg, Benjamin Mayer, Hans-Peter Müller, Martin Gorges, Angela Rosenbohm, Alexander E Volk, Vincenzo Silani, Albert C Ludolph, Markus Otto
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Summary:<h3>Objective</h3> <p>To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS).</p><h3>Methods</h3> <p>This single-centre, prospective, longitudinal study included the following patients: 124 patients with ALS; 50 patients without neurodegenerative diseases; 44 patients with conditions included in the differential diagnosis of ALS (disease controls); 65 patients with other neurodegenerative diseases (20 with frontotemporal dementia, 20 with Alzheimer’s disease, 19 with Parkinson’s disease, 6 with Creutzfeldt-Jakob disease (CJD)). Serum NFL levels were measured using the ultrasensitive single molecule array (Simoa) technology.</p><h3>Results</h3> <p>Serum NFL levels were higher in ALS in comparison to all other categories except for CJD. A cut-off level of 62 pg/mL discriminated between ALS and all other conditions with 85.5% sensitivity (95% CI 78% to 91.2%) and 81.8% specificity (95% CI 74.9% to 87.4%). Among patients with ALS, serum NFL correlated positively with disease progression rate (r<sub>s</sub>=0.336, 95% CI 0.14 to 0.506, p=0.0008), and higher levels were associated with shorter survival (p=0.0054). Serum NFL did not differ among patients in different ALS pathological stages as evaluated by diffusion-tensor imaging, and in single patients NFL levels were stable over time.</p><h3>Conclusions</h3> <p>Serum NFL is increased in ALS in comparison to other conditions and can serve as diagnostic and prognostic biomarker. We established a cut-off level for the diagnosis of ALS.</p>
Item Description:Published online first 11 October 2018
Gesehen am 16.06.2021
Physical Description:Online Resource
ISSN:1468-330X
DOI:10.1136/jnnp-2018-318704

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